Question

Difference between acanthosis and acantholysis

Answer 1

acanthosis is a diffuse epidermal hyperplasia .It implies increased thickness of Malpighian layer

acantholysis is a loss of inter celluar connections

Answer 2

Hi my dear frnd,

Acantholysis is the loss of intercellular connections, such as desmosomes, resulting in loss of cohesion between keratinocytes,seen in diseases such as pemphigus vulgaris. It is absent in bullous pemphigoid, making it useful for differential diagnosis.


Acanthosis is diffuse epidermal hyperplasia (thickening of the skin). It implies increased thickness of the Malpighian layer (stratum basale and stratum spinosum).

I hope it is helpful for u