Difference between glycated and glycosylated hemoglobin
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Hello,
Both glycation and glycosylation refers to addition of sugars to other molecules like protein.
Glycation is a non-enzymatic process while glycosylation is an enzymatic process.
Glycated hemoglobin is the well known example for glycation.
Glycoproteins are examples for glycosylation. Various glycosyl transferase enzymes are involved in glycosylation.
Think of glycosylation as an umbrella term for adding one or many sugars to something. The addition requires an enzyme as the reaction is too difficult without one. Since enzymes are involved we can add sugars to many things that aren't usually reactive. Cells in the body have many reasons for doing this. But just know enzymes are needed for this reaction.
Glycation, on the other hand, is not something cells want within their proteins; as it can make them not work properly. In high sugar concentrations, the sugars will start to bond to reactive portions on and within proteins. This can have bad results for cells. But this process doesn't need an enzyme present, a high concentration of sugar will increase the chances of these sugars binding to important reactive structures within and around the cell.
Glycation and glycosylation are similar but they happen for different reasons and need certain things to be present. That's were they differ.
I hope that helps
Both glycation and glycosylation refers to addition of sugars to other molecules like protein.
Glycation is a non-enzymatic process while glycosylation is an enzymatic process.
Glycated hemoglobin is the well known example for glycation.
Glycoproteins are examples for glycosylation. Various glycosyl transferase enzymes are involved in glycosylation.
Think of glycosylation as an umbrella term for adding one or many sugars to something. The addition requires an enzyme as the reaction is too difficult without one. Since enzymes are involved we can add sugars to many things that aren't usually reactive. Cells in the body have many reasons for doing this. But just know enzymes are needed for this reaction.
Glycation, on the other hand, is not something cells want within their proteins; as it can make them not work properly. In high sugar concentrations, the sugars will start to bond to reactive portions on and within proteins. This can have bad results for cells. But this process doesn't need an enzyme present, a high concentration of sugar will increase the chances of these sugars binding to important reactive structures within and around the cell.
Glycation and glycosylation are similar but they happen for different reasons and need certain things to be present. That's were they differ.
I hope that helps
Answered by
455
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━☞Serum free hemoglobin is a blood test that measures the level of free hemoglobin in the liquid part of the blood (the serum).
━☞ Free hemoglobin is the hemoglobin outside of the red blood cells. Most of the hemoglobin is found inside the red blood cells, not in the serum. Hemoglobin carries oxygen in the blood......
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