dimerization of arginyl-trna synthetase by free heme drives its inactivation in plasmodium falciparum
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Excess cellular heme is toxic, and malaria parasites regulate its levels during hemoglobin digestion. ... These data together suggest that the inhibition of Plasmodium falciparum arginyl-tRNA synthetase can now be synergized with existing antimalarials for more potent drug cocktails against malaria parasites.
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