DNA is an acid but has the pH of an alkaline and is stable. How?
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The hydroxide ion concentration and pH have a direct correlation, meaning the higher the pH, the higher the hydroxide concentration. Likewise, the lower the hydrogen ion concentration falls. At high pH, then, the solution is rich in hydroxide ions, and these negatively-charged ions can pull hydrogen ions off of molecules like the base pairs in DNA. This process disrupts the hydrogen bonding that holds the two DNA strands together, causing them to separate.
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