Question

Doxorubicin drug dosing concentration on mcf-7 cells and hek cells

Answer 1

Silencing with siG2-2 restored sensitivity to approximately 80–85% of the parental levels. Together with the results from the FTC cytotoxicity studies, this suggests that ABCG2 is critical for the drug resistance in the single-step 21 nM doxorubicin-selected MCF-7 cells.