E.baur reported a lethal gene in
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When yellow coated mice was crossed with another yellow coated mice, segregation for yellow and brown body colour was obtained in 2: 1 ratio. The brown individuals were pure and homozygous where as yellow individuals were heterozygous. These results may be explained on the assumption that the dominant allele for yellow body colour is lethal in homozygous condition.
(Inheritance of yellow coated colour in mice. Mice with yellow coated colour are always heterozygous.)
E. Baur (1907) observed lethal gene in Snapdragon (Antirrhinum) and found that it is characterized by variegated leaves. The “golden” variety on selfing gives rise to 2 types of offsprings, golden and green in the ratio of 2:1 instead of 3: 1. The golden ones are heterozygous and the green ones breed true being recessive homozygous.