Question

estrogen receptor related receptor receptors in human ovarian endometrosis

Answer 1

OBJECTIVE:

To determine whether decreased estrogen receptor alpha (ER-α) expression in endometriotic lesions could be balanced by an increased expression of estrogen receptor-related receptors (ERRs). To evaluate whether ERR-α expression is influenced by hormonal change in fertile and menopausal women.

DESIGN:

Prospective controlled study.

SETTING:

University Hospital, Department of Gynecology.

PATIENT(S):

Twenty-five women: 20 women of reproductive age with (n = 10) and without (control; n = 10) endometriosis and 5 menopausal women.

INTERVENTION(S):

Real-time polymerase chain reaction (qPCR). Immunohistochemistry.

MAIN OUTCOME MEASURE(S):

The ER and ERR expression levels were studied by reverse transcriptase-qPCR, ELISA, and immunohistochemistry using endometriotic and normal endometrial tissues. The ERR-α protein distribution was performed by immunohistochemistry in fertile and menopausal women.

RESULT(S):

Increased levels of ER-β were associated with ER-α, ERR-α, and ERR-γ reductions in ectopic tissue but not in eutopic and normal endometria. Similar levels of ERR-β were found in women with and without endometriosis. The ERR-α expression was similar in proliferative and secretory endometrial samples, whereas a down-regulation of this receptor was found in atrophic tissue.

CONCLUSION(S):

Our data confirm the up-regulation of ER-β as the principal receptor involved in the progression of human endometriosis. In addition, we found that ERR-α seems to be unresponsive to hormonal changes during the menstrual cycle.

Answer 2

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Here's your answer mate

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Receptor✍

• Receptors are cells tissues and organs which are capable of receiving particular stimuli and initiate impulse picked up by sensory nerves

✰Hope it helps❢❢

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