Question

Explain mechanism of action and adverse effects of tetracyclines. (Pharmacology - lV)

Answer 1

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Mechanism of action. Tetracycline inhibits protein synthesis by blocking the attachment of charged aminoacyl-tRNA to the A site on the ribosome. Tetracycline binds to the 30S subunit of microbial ribosomes. ... This accounts for the relatively small off-site effect of tetracycline on human cells.