Question

Explain Skraup synthesis of Quinoline compounds .
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Answer 1

Answer:

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Explanation:

The Combes quinoline synthesis is a chemical reaction, which was first reported by Combes in 1888. It involves the condensation of unsubstituted anilines (1) with β-diketones (2) to form substituted quinolines (4) after an acid-catalyzed ring closure of an intermediate Schiff base (3). The Skraup synthesis is a chemical reaction used to synthesize quinolines. In the archetypal Skraup reaction, aniline is heated with sulfuric acid, glycerol, and an oxidizing agent such as nitrobenzene to yield quinoline. ... In this example, nitrobenzene serves as both the solvent and the oxidizing agent.

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Answer 2

Answer:

The Combes Quinoline synthesis is a chemical reaction, which was first reported by Combes in 1888. It involves the condensation of unsubstituted anilines (1) with β-diketones (2) to form substituted quinolines (4) after an acid-catalyzed ring closure of an intermediate Schiff base.

Explanation:

The Skraup synthesis is a chemical reaction used to synthesize quinolines. In the archetypal Skraup reaction, aniline is heated with sulfuric acid, glycerol, and an oxidizing agent such as nitrobenzene to yield quinoline. In this example, nitrobenzene serves as both the solvent and the oxidizing agent.