Explain structure and funtion of hemoglobin myoglobin hemicyanin hemierithrine
Answers
Answer:Hemoglobin:
1st. protein whose molecular weight was determined
1st protein to be assigned a specific function - dioxygen transport
has a prosthetic group (non-amino acid) heme group (protoporphyrin IX with a ferrous ion) covalently attached to the protein. The heme group binds dioxygen.
1st protein in which a point mutation (single base pair charge) causes a single amino acid change in the protein, marking the start of molecular medicine
1st protein with high resolution x-ray structure
theory for dioxygen binding explain control of enzyme activity
the binding of dioxygen is regulated by binding of H+, CO2, and bisphosphoglcyerate which bind to sites (allosteric) distant from oxygen binding site.
crystals of deoxy-Hb shatter on binding dioxygen, indicating significant conformational changes on binding.
Myoglobin
Mb is extremely compact, and consists of 75% alpha helical structure.
8 α−helices are present, labeled A-H.
4 alpha helices are terminated by Pro
The interior amino acids are almost entirely nonpolar. The only polar amino acids found completely buried are the two His (proximal and distal) found at the active site of dioxygen binding.
Explanation: