explain various strains of dengue
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Dengue is an acute febrile disease caused by the mosquito-borne dengue viruses (DENVs), consisting of four serotypes (DENV 1 to 4), that are members of the flaviviridae family, genus flavivirus . All four DENV serotypes have emerged from sylvatic strains in the forests of South-East Asia..
Cuban studies have shown that stored serum sample analysis demonstrated progressive loss of cross-reactive neutralizing antibodies to DENV-2 as the interval since DENV-1 infection increased. [28] In addition, certain dengue strains, particularly those of DENV-2, have been proposed to be more virulent, in part because more epidemics of dengue hemorrhagic fever have been associated with DENV-2 than with the other serotypes.
DENV-2–activated platelets were phagocytized in large numbers when the platelet activation inhibitor prostacyclin was added.