Factors affecting genetic equilibrium random mating
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The Hardy-Weinberg equilibrium can be disturbed by a number of forces, including mutations, natural selection, nonrandom mating, genetic drift, and gene flow. For instance, mutations disrupt the equilibrium of allele frequencies by introducing new alleles into a population.
When a population is in Hardy-Weinberg equilibrium for a gene, it is not evolving, and allele frequencies will stay the same across generations. ... They are: mutation, non-random mating, gene flow, finite population size (genetic drift), and natural selection.
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