Question

For a gene present on human chromosome 4, the maximum number of alleles that may be detected

by sequencing the genom
e of 5 males and 10female​

Answer 1

Answer:

Human Chromosomes

Human ChromosomesHuman chromosomes were probably first observed in cancer cells by Arnold in 1879. Hansemann in 1881 and Flemming in 1898 attempted to count the number in serial sections of mitotic cells producing crude estimates of approximately 24. Quite different results were produced in 1912 by de Winiwarter. He was probably the first to study gonadal material and found 47 chromosomes in testis and 48 in ovary. He concluded that humans, like the locust, have an XX female/X male sex-determining mechanism. Painter, in 1923, repeated this work on sections of testis material, in which he detected the small Y chromosome which de Winiwarter had apparently missed. He concluded that 48 and not 47 was the correct number for humans of both sexes, but mentioned in his publication that in the clearest mitotic figures he could count only 46.

Human ChromosomesHuman chromosomes were probably first observed in cancer cells by Arnold in 1879. Hansemann in 1881 and Flemming in 1898 attempted to count the number in serial sections of mitotic cells producing crude estimates of approximately 24. Quite different results were produced in 1912 by de Winiwarter. He was probably the first to study gonadal material and found 47 chromosomes in testis and 48 in ovary. He concluded that humans, like the locust, have an XX female/X male sex-determining mechanism. Painter, in 1923, repeated this work on sections of testis material, in which he detected the small Y chromosome which de Winiwarter had apparently missed. He concluded that 48 and not 47 was the correct number for humans of both sexes, but mentioned in his publication that in the clearest mitotic figures he could count only 46.There matters stood until 1956, when Tjio and Levan, working on colchicinized cell cultures treated with hypotonic fluid before fixation, regularly counted only 46 chromosomes, in samples from different cultures. This number was confirmed as the correct number by Ford and Hamerton using testis material later the same year. The normal complement of human chromosomes is designated as 46,XX for females and 46,XY for males.

Answer 2

Human Chromosomal DNA Arnold most likely found human chromosomes for the first time in cancer cells in 1879.

• A rough estimate of 24 was produced by Hansemann and Flemming's attempts to count the number of mitotic cells in serial sections in 1881 and 1898, respectively.
• The Winiwarter generated remarkably diverse outcomes in 1912.
• 47 chromosomes were discovered in the testis and 48 in the ovary.
• He was likely the first to investigate gonadal material.
• He came to the conclusion that people also have a XX female/X male sex-determining mechanism.
• The tiny Y chromosome that de Winiwarter had ostensibly missed was found by Painter in 1923 when he performed this technique on portions of testis material.
• Although he noted in his publication that he could only count 46 in the clearest mitotic figures, he came to the conclusion that 48, not 47, was the right amount for humans of both sexes.

Human Chromosomal DNA

• Arnold most likely found human chromosomes for the first time in cancer cells in 1879.
• A rough estimate of 24 was produced by Hansemann and Flemming's attempts to count the number of mitotic cells in serial sections in 1881 and 1898, respectively.
• The Winiwarter generated remarkably diverse outcomes in 1912.
• 47 chromosomes were discovered in the testis and 48 in the ovary.
• He was likely the first to investigate gonadal material.
• He came to the conclusion that people also have a XX female/X male sex-determining mechanism.
• The tiny Y chromosome that de Winiwarter had ostensibly missed was found by Painter in 1923 when he performed this technique on portions of testis material.
• Although he noted in his publication that he could only count 46 in the clearest mitotic figures, he came to the conclusion that 48, not 47, was the right amount for humans of both sexes.
• The situation remained unchanged until 1956, when Tjio and Levan, working on colchicine-fixed cell cultures treated with hypotonic fluid before fixation, discovered that samples from various cultures consistently contained just 46 chromosomes.
• During that year, utilising testis material, Ford and Hamerton were able to confirm that this number was accurate.
• Human chromosomes typically have a complement of 46,XX for females and 46,XY for males.

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