Question

Give the mechanism and factors affecting on dermal penitration of drug.

Answer 1

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$\large\underline\mathfrak\green{Dermal\:penitration\:of\:drug}:$

Administration of drug through skin is called trans-dermal administration.

Mechanism of drug penetration:

• The hair follicles with their associated sebaceous glands,

• The the sweat ducts;

• (Transcellular or Intercellular) across the continuous stratum corneum between these appendages

Factors influencing drug absorption through this route are:

• Skin hydration.

• Temperature and pH.

• Diffusion coefficient

• Drug concentration

• Partition coefficient

• Molecular size and shape

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