Question

Hello!
I am a pharmaceutical student, I am asked to do a research about "Indirect neutralization titration"
I really need help, I am asked to explain how it is done and explain some examples of determinations.
The problem is .. I can't find the information on the internet and I have no time . I need references.

Answer 1

Answer:

Explanation:

its is a two stage technique used under certain circumstances.

first the substance to be estimated A is reacted with B in excess.. and then amount of B remaining is estimated using standard titration then the amount of B consumed inn reaction with A can be calculated hence the strength of A

this is used if A is volatile like ammonia

A is insoluble like calcium carbonate

or the particular titiration reaction of A is very slow

for example u r given a ammonia solution it is cloudy and has lot of vapours as it is volatile . the actual concentration cant be determined if u do a direct titration . so pipette out some amount of this cloudy solution to a flask add excess hcl  with known concentration and volume into the flask make sure all the ammonia is reacted. Now the remaining amount of HCl in the flask can be estimated  using a base like sodium carbonate and hence we can calculate amount of HCl reacted previously with ammonia as we know the initial volume of hcl used. find the amount reacted with ammonia and we can calculate the concentration of ammonia

for insoluble salts like calcium carbonate . if u want to estimate amount of calcium carbonate in a piece of bone . power the bone sample. but it wont dissolve in water . add hcl in excess of known volume and concentration to bone sample until all the calcium carbonate gets reacted . now estimate remaining amount of hcl and find out amount of hcl reacted with calcium carbonate.. follow remaining steps as in previous case