How are antibodies produced in a person with a blood group?
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The immune system forms antibodiesagainst whichever ABO blood group antigens are not found on theindividual's RBCs. ... Blood group AB is the least common, and these individuals will have neither anti-A nor anti-B in their serum. ABO antibodies in the serum are formed naturally.
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Very simple explanation: the body makes antibodies to molecules it encounters which it doesn't recognise, but it won't (usually) make antibodies to its own components. A baby with blood group B is born with B on its red cells - but no anti-A. It will make that around the time it's weaned. We THINK the anti-A and anti-B antibodies are raised against complex carbohydrates in foods, which happen to cross react with the A and B antigen.
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