Question

How do detergents solubilize membrane proteins?

Answer 1

hello friend here is your answer.
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Denaturing detergents such as SDS bind to both membrane(hydrophobic) and non-membrane (water-soluble, hydrophilic) proteins at concentrations below the CMC (i.e., as monomers). ... Detergentmonomers solubilize membrane proteins by partitioning into themembrane bilayer.

Answer 2

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Detergent monomers solubilize membrane proteins by partitioning into the membrane bilayer. ... Increasing the ratio to 2:1, solubilization of the membrane occurs, resulting in mixed micelles. These include phospholipid–detergent micelles, detergent–protein micelles, and lipid–detergent–protein micelles.