How do endoplasmic reticulum and ribosome coordinate in protein synthesis?
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Ribosomes, the endoplasmic reticulum and the Golgi apparatus are related to each other through their involvement in protein synthesisand transport. Ribosomes are the sites ofprotein synthesis and carry out this work by assembling the amino acids in the appropriate sequence, as dictated by the mRNA (messenger RNA).
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Translation of secretory or integral membrane proteins initiates in the cytosol, then ribosomes containing these mRNAs are recruited to the ER membrane via a signal sequence within the amino terminus of the nascent polypeptide that is recognized and bound by the signal recognition particle (SRP) [9, 10].
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