Question

How does alcohol affect cerebellum?

Answer 1

when we drink alcohol cerebellum detect the alcohol and make then hot as his work

Answer 2

The cerebellum influences movejments primarily by modifying the activity patterns of the upper motor neurons. Its primary function is to detect the difference, or "motor error," between an intended movement and the actual movement (6). One factor that can disrupt this function is the introduction of alcohol into the blood. When alcohol is consumed at a rate faster than it can be metabolized by the body, the function of most major brain structures is altered (4). The effect of alcohol on the cerebellum presents primarily as a loss of coordinated movement and balance along with an ataxic gait (1,4). It has been proposed that one of the main mechanisms by which alcohol affects the cerebellum is via increased GABAergic inhibition of cerebellar granule cells resulting from increased output of the neurotransmitter GABA from the Golgi cells (8, 9). Chronic alcohol consumption can leave long term effects on the cerebellum. These effects are mainly secondary to cerebellar degeneration, which can result in permanent gait ataxia and memory loss (4, 5). Further research on the effect of alcohol during the development of the cerebellum can be seen in children who have fetal alcohol syndrome. Consumption during pregnancy has been shown to lead to reduced size of the cerebellum causing poor coordination of movement.