How does blocking 5ht2 receptor increase serotonin?
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They rapidly block serotonin (5-HT) reuptake, yet the onset of their therapeutic action requires weeks of treatment. ... The blockade of 5-HT2A receptors also seems to improve the clinical effects of SSRIs. These receptors are located postsynaptically to 5-HT axons, mainly in the neocortex.
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