How does stereoisomerism features affect the pharmacodynamic effect?
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Many drugs used in clinical practice contain one or more chiral centers. These chiral drugs are often used therapeutically either as pure stereoisomers or as a racemic mixture. The three dimensional interaction of two enantiomers with a macromolecule, such as an enzyme or receptor, to form diastereomeric complexes may result in chiral recognition and significant differences in pharmacokinetic processes as well as
the pharmacodynamics.
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