how is HBH inclusion are pitted by spleen
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Hemoglobin H bodies. Hemoglobin H, consisting of beta chain tetramers, is an unstable hemoglobin which forms precipitates just below the red blood cell membrane. This precipitated hemoglobin inclusion can be observed when red blood cells are stained with Brilliant Cresyl Blue (BCB
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Ineffective erythropoiesis causes the appearance of hypochromic red cells, with a clear center and darker rim containing the hemoglobin (target cells). The precipitates form inclusions, called Heinz bodies, which are removed (“pitted out”) by the spleen with consequent membrane damage.
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