Question

How is propan-1-ol synthesised by using Grignard reagent ?

Answer 1

CH3-CH3-CH2OH + R-MgX ---> CH3CH3CH2-OMgX + R-H(alkane)

Answer 2

Propan-1-ol synthesised by using Grignard reagent and reacting it with formaldehyde.

Explanation:

• The addition of magnesium metal to alkyl or alkenyl halides produces Grignard reagents. Cl, Br, or I can be used as the halide (not F). However, making Grignards from iodides and bromides is slightly easier.

• The Grignard reagent is reacted with formaldehyde to make a primary alcohol. A secondary alcohol is formed when a Grignard reagent is combined with any other aldehyde. Finally, a tertiary alcohol is produced by reacting a Grignard reagent with a ketone.

• Formaldehyde reacts with Grignard reagent to generate a complex, C2H5 – Mg – I in dry ether, which is then hydrolyzed with dilute HCI to form Propan-l-ol.