how isoelectric point useful in maintaining pH in human system
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Because a majority of weakly acid remains in nearly every protein, they are generally negatively charged at neutral pH. The isoelectric point is significant in protein purification because it represents the pH where solubility is typically minimal.
The isoelectric point (pI, pH(I), IEP), is the pH at which a particular molecule carries no net electrical charge or is electrically neutral in the statistical mean. The standard nomenclature to represent the isoelectric point is pH(I),[1] although pI is also commonly seen,[2] and is used in this article for brevity. The net charge on the molecule is affected by pH of its surrounding environment and can become more positively or negatively charged due to the gain or loss, respectively, of protons (H+).
Surfaces naturally charge to form a double layer. In the common case when the surface charge-determining ions are H+/OH−, the net surface charge is affected by the pH of the liquid in which the solid is submerged.
