How to determine cell mass concentration at steady state?
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most clinical situations, drugs are administered as fixed doses at set intervals or as a continuous infusion, not as an intravenous-bolus or single-extravascular dose. The term steady state (Css) refers to the concentration of drug in the systemic circulation when the rate of drug elimination is equal to the rate of drug administration. As long as a drug follows first-order kinetics, this administration pattern will eventually result in a steady-state concentration in plasma that is intended to be within the therapeutic window for that agent (see the record on Multiple Drug Dosing Schedules). For a drug administered by intravenous infusion, the steady-state level is calculated as:
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