Question

how to determine r and s in fishers projection...?​

Answer 1

Answer:

ANSWER IS GIVEN BELOW

Explanation:

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An easy way to find the R / S configuration of a molecule with more than one chiral center is with a Fischer projection. A Fischer projection is a convenient two-dimensional drawing that represents a three-dimensional molecule. To make a Fischer projection, you view a chiral center so that two substituents are coming out of the plane at you, and two substituents are going back into the plane, as shown here. Then the chiral center becomes a cross on the Fischer projection. Every cross on a Fischer projection is a chiral center.

Creating a Fischer projection -- it is in first pic

Fischer projections are convenient for comparing the stereochemistries of molecules that have many chiral centers. But these projections have their own sets of rules and conventions for how you can rotate and move them.

As shown here, the two main ways to rotate a Fischer projection are as follows:

Working with Fischer projections. It is in second pic.

You can rotate a Fischer projection 180 degrees and retain the stereochemical configuration, but you cannot rotate a Fischer projection 90 degrees.

You can rotate any three substituents on a Fischer projection while holding one substituent fixed and retain the stereochemical configuration.

Here’s how to determine the configuration of a chiral center drawn in a Fischer projection. First, you prioritize each of the substituents using the Cahn–Ingold–Prelog prioritizing scheme.

Answer 2

The Fischer projection is an early solution to the problem of drawing 3-dimensional molecules on a 2-dimensional page. Think of a light source illuminating a 3-dimensional object that casts a shadow on a flat surface. If these

objects are always arranged in a consistent way, we can infer the 3-D structure of the object from the shadow. In the days before dashes, wedges, and the CIP rules, that’s what Fischer was going for.

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