Question

How to prevent sulphonamide precipitation and crystaluria?

Answer 1

. The solubilities of sulfa-diazine and particularly of acetyl sulfadiazine, in buffers and in normal urine, increase markedly with increasing pH within the physi-ological pH range of urine. 2. Examination of urine specimens from patients receiving sulfadiazine has demonstrated that crystal-luria due to sulfadiazine can be prevented by maintaining the urine neutral or alkaline and the volume within limits generally considered optimum for patients with infection. 3. This study affords evidence that renal reactions due to the precipitation of sulfadiazine compounds can be prevented by appropriate alkali and fluid therapy. Our clinical findings to date accord with this assumption.