Human blood has a narrow pHpH range of 7.3−7.47.3−7.4, which must be maintained for metabolic processes to function properly. To keep the pHpH in this range, requires a delicate balance between the concentrations of the conjugate acid-base pairs, making up to the buffer system. The main buffer is a carbonic acid-hydrogen carbonate system, which involves the following equilibria:
CO2(g)⇋CO2(aq)CO2(g)⇋CO2(aq)
CO2(aq)+H2O(l)⇋H2CO3(aq)CO2(aq)+H2O(l)⇋H2CO3(aq)
H2CO3(aq)+H2O(l)⇋HCO−3(aq)+H3O+(aq)H2CO3(aq)+H2O(l)⇋HCO3−(aq)+H3O+(aq)
At the body temperature, the pKapKa for carbonic acid is 6.406.40. However, the normal concentration of CO2(g)CO2(g) in the lungs maintains a ratio of HCO−3(aq)HCO3−(aq) and H2CO3(aq)H2CO3(aq) in blood plasma at about 8:18:1. H2CO3H2CO3 concentration in the blood is largely controlled by breathing and respiration and HCO−3HCO3− concentration is largely controlled by excretion in urine.
If blood pHpH rises above 7.47.4, a potentially life-threatening condition called alkalosis can result. It normally occurs in climbers suffering from oxygen defciency at high altitude or in patients who are hyperventilating from severe anxiety. (log2=0.3log2=0.3)
The maximum permissible value of [H2CO3][HCO−3][H2CO3][HCO3−] in human blood to just prevent alkalosis is
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