HvZ reaction
is used to prepare
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The Hell–Volhard–Zelinsky halogenation reaction halogenates carboxylic acids at the α carbon. ... In its first step, a combination of bromine and phosphorus tribromide (catalyst) is used to prepare 2-bromopropanoic acid, which is then converted to a racemic mixture of the amino acid product by ammonolysis.
Explanation:
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The hell-volhard-Zelinsky reaction is used for preparing α - haloacid
Explanation:
- The hell Volhard Zelinsky reaction involves very harsh reaction conditions, including reaction temperatures exceeding 373 K and prolonged reaction times.
- Usually, less than one equivalent of phosphorous is needed for the reaction (or a trihalide of phosphorous).
- Without the aid of a catalyst, some carboxylic acids and their derivatives, such as acyl halides and anhydrides, can undergo halogenation.
- The HVZ Reaction is illustrated in the example below.
- The fluorination and iodination of carboxylic acids cannot be achieved by the HVZ reaction.
- Beta unsaturated carboxylic acids may develop as a result of the removal of hydrogen halide from the product of the Hell-Volhard-Zelinsky reaction at extremely high temperatures.
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