Question

Hyponatremia in stroke and response to saline infusion

Answer 1

Cerebral salt wasting (CSW), also known as renal salt wasting, is a hyponatremic state that mimics all of the laboratory findings observed in the syndrome of inappropriate antidiuretic hormone (SIADH) secretion. The only clinical difference is the state of the extracellular volume (ECV) being hypovolemic in CSW and euvolemic or hypervolemic in SIADH. CSW is defined as ECV depletion due to a renal sodium transport abnormality with or without high urinary sodium concentration, the presence of hyponatremia, or cerebral disease with normal adrenal and thyroid functions.