Question

If division and differentiation are concurrent then growth will be

Answer 1

cell-cycle arrest may be necessary for differentiation, but it is not always sufficient. Oligodendrocyte differentiation involves both changes in gene expression and concurrent cell cycle arrest. In order to determine whether cell-cycle arrest is sufficient to cause differentiation, Tang et al.[4] inhibited proliferation of oligodendrocyte precursors in vitro by overexpressing p27, a well-known Cdk inhibitor. They discovered that the precursors stopped dividing, but did not express proteins associated with differentiation. This suggests that cell-cycle arrest per se is not sufficient for differentiation, and that other signaling pathways are also needed.