In vitro in situ and in vivo methods to determine permeability
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In silico methods
The in silico prediction methods have acquired popularity in the last few decades in the BBB research because of their speed, flexibility, low cost and less time-consuming efforts in comparison to in vitro and in vivo approaches. Therefore, a new strategy has evolved based on the computational simulation and prediction of compound interaction with the BBB interface to expedite and improve rational drug design and discovery at its early stage.
ln Vitro methods
In CNS research, BBB permeability properties of drug-like candidates are very important. Systems that can be used for HTS are favoured. Moreover, methods that allow for direct access to the brain endothelium with no interference from other brain structures are preferred. In vitro models allow for this which are the more common choice for such purpose. The translation of in vivo BBB permeability research to an in vitro setting calls for efficient in vitro methods of assessment.
The in silico prediction methods have acquired popularity in the last few decades in the BBB research because of their speed, flexibility, low cost and less time-consuming efforts in comparison to in vitro and in vivo approaches. Therefore, a new strategy has evolved based on the computational simulation and prediction of compound interaction with the BBB interface to expedite and improve rational drug design and discovery at its early stage.
ln Vitro methods
In CNS research, BBB permeability properties of drug-like candidates are very important. Systems that can be used for HTS are favoured. Moreover, methods that allow for direct access to the brain endothelium with no interference from other brain structures are preferred. In vitro models allow for this which are the more common choice for such purpose. The translation of in vivo BBB permeability research to an in vitro setting calls for efficient in vitro methods of assessment.
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