Biology, asked by viveksingh2901, 1 year ago

Inducible and reversible phenotypes in a novel mouse model of friedreichs ataxia

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Answered by prateek7516
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ataxia is the correct answer that's right for you

Answered by RAJSHIVAMSINGH2005
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Answer:Friedreich's ataxia (FRDA), the most common inherited ataxia, is caused by recessive mutations that reduce the levels of frataxin (FXN), a mitochondrial iron binding protein. We developed an inducible mouse model of Fxn deficiency that enabled us to control the onset and progression of disease phenotypes by the modulation of Fxn levels. Systemic knockdown of Fxn in adult mice led to multiple phenotypes paralleling those observed in human patients across multiple organ systems

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