Inference of mitosis
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The fraction labelled mitoses curve is widely used to study the premitotic phase of the cell cycle in proliferating cell populations. The population is here assumed to be in a steady state of exponential growth. The theoretical curve is derived in an explicit computational form, allowing for correlations between phases. This gives the likelihood function explicitly, and classical maximum likelihood methods of fitting the theoretical curve to experimental data can work very well. The curve may often be approximated by assuming a joint normal distribution of phase times, and computation of the curve and of the maximum likelihood estimates then becomes straightforward. The mitotic index may sometimes be used to give supplementary information about the mean mitotic time. Weak inferences about the presence of absence of negative correlations between certain phases are possible. The methods are illustrated with three examples of experimental data.
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QUESTION:-
Inference of mitosis
ANSWER:-
INFERENCE OF MITOSIS IS:-
- Mitosis is a process in a eukaryotic cell in which its nucleus splits in two, which emerges division of the parent cell into two daughter cells.
- Mitosis is the process of division of the nucleus, this process occurs just before the division of cells or cytokinesis.
- During the process of Mitosis, the chromosomes of the cell condense and the spindle assembles.
- The spindle is attached to the duplicated chromosomes, they are aligned at the cell equator, and automatically shift apart as the spindle micro-tubule withdraws towards the opposing poles of the cell.
- Each set of chromosomes is gets surrounded by a thin membrane called a nuclear membrane, and the parent cell splits into two daughter cells.
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