Question

"insertion or deletion of three or its multiple bases insert or delete in one or multiple codon hence one or multiple amino acids and reading frame remains unaltered from that point onwards" can someone explain this statement​

Answer 1

Answer:

Hey mate...

Explanation:

Types of Mutations: Deletion and Insertion

Genes can also be mutated by the deletion or insertion of a number of nucleotide bases. There are different types of deletions or insertions.

Frameshift mutations occur when the number of deleted or inserted base pairs is NOT a multiple of three. Since codons consist of three base pairs, if, for example, only one or two base pairs are deleted, then the way the DNA is read is shifted at the place of the deletion or insertion. After the place of the mutation, ALL of the amino acids that follow will be different. In this case, either an abnormal protein is made or no protein is made at all.

In-frame mutations occur when the number of deleted or inserted base pairs IS a multiple of three. This results in a change in only a few amino acids; it may still be possible for the protein to function, even though its sequence may be slightly different.

Answer 2

Point mutations are referred to as such when heritable changes take place in a very short region of the DNA molecule, such as a single nucleotide or nucleotide pair.

• The following forms of sub nucleotide changes in DNA and RNA can result in point mutations.
• Deletion mutations- Deletion mutation refers to the point mutation that results from the loss or deletion of a section (single nucleotide pair) in a triplet codon of a cistron or gene.
• Mutation via insertion or addition- Insertion mutations are point mutations that happen when one or more nucleotides get added to a cistron or gene.

• The insertion or deletion of nucleotide bases in amounts that are not multiples of three is referred to as a frameshift mutation in a gene.
• This is significant because a cell reads the genetic code for proteins in groups of three nucleotides.
• These so-called "triplet codons" each stand for one of the 20 different amino acids that go into making a protein.
• The entire gene sequence after the mutation will be misread if a mutation alters this regular reading frame.
• This may lead to the incorrect amino acids being added to the protein or the development of a codon that prevents the protein from getting longer.

• But if the addition or deletion of 3 or multiple of 3 amino acids take place, then the reading frame does not get altered, it just alters one single codon.

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