Interactions between the red blood cell and important molecules, cells, and organs
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The red blood cells are highly specialized, well adapted for their primary function of transporting oxygen from the lungs to all of the body tissues. Red cells are approximately 7.8 μm (1 μm = 0.000039 inch) in diameter and have the form of biconcave disks, a shape that provides a large surface-to-volume ratio. When fresh blood is examined with the microscope, red cells appear to be yellow-green disks with pale centres containing no visible internal structures. When blood is centrifuged to cause the cells to settle, the volume of packed red cells (hematocrit value) ranges between 42 and 54 percent of total volume in men and between 37 and 47 percent in women; values are somewhat lower in children. Normal red blood cells are fairly uniform in volume, so that the hematocrit value is determined largely by the number of red cells per unit of blood. The normal red cell count ranges between four million and six million per cubic millimetre.
The red blood cell is enclosed in a thin membrane that is composed of chemically complex lipids, proteins, and carbohydrates in a highly organized structure. Extraordinary distortion of the red cell occurs in its passage through minute blood vessels, many of which have a diameter less than that of the red cell. When the deforming stress is removed, the cell springs back to its original shape. The red cell readily tolerates bending and folding, but, if appreciable stretching of the membrane occurs, the cell is damaged or destroyed. The membrane is freely permeable to water, oxygen, carbon dioxide, glucose, urea, and certain other substances, but it is impermeable to hemoglobin. Within the cell the major cation is potassium; in contrast, in plasma and extracellular fluids the major cation is sodium. A pumping mechanism, driven by enzymes within the red cell, maintains its sodium and potassium concentrations. Red cells are subject to osmotic effects. When they are suspended in very dilute (hypotonic) solutions of sodium chloride, red cells take in water, which causes them to increase in volume and to become more spheroid; in concentrated salt solutions they lose water and shrink.
The red blood cell is enclosed in a thin membrane that is composed of chemically complex lipids, proteins, and carbohydrates in a highly organized structure. Extraordinary distortion of the red cell occurs in its passage through minute blood vessels, many of which have a diameter less than that of the red cell. When the deforming stress is removed, the cell springs back to its original shape. The red cell readily tolerates bending and folding, but, if appreciable stretching of the membrane occurs, the cell is damaged or destroyed. The membrane is freely permeable to water, oxygen, carbon dioxide, glucose, urea, and certain other substances, but it is impermeable to hemoglobin. Within the cell the major cation is potassium; in contrast, in plasma and extracellular fluids the major cation is sodium. A pumping mechanism, driven by enzymes within the red cell, maintains its sodium and potassium concentrations. Red cells are subject to osmotic effects. When they are suspended in very dilute (hypotonic) solutions of sodium chloride, red cells take in water, which causes them to increase in volume and to become more spheroid; in concentrated salt solutions they lose water and shrink.
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