Biology, asked by minha7739, 1 year ago

Intraperitoneal immunotherapy with t cells stably and transiently expressing anti-epcam car in xenograft models of peritoneal carcinomatosis.

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Answered by ajmal64

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The epithelial cell adhesion molecule (EpCAM) is overexpressed in a wide variety of tumor types, including peritoneal carcinomatosis (PC) from gastrointestinal and gynecological malignancies. ... Thus, our study demonstrates the effectiveness of using anti-EpCAM CAR-expressing T cells for local treatment of PC in mice.

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