Is it true that the fertilization antigen - 1 is vaccine?
Answers
Fertilization antigen (FA-1), the ideal antigen for the development of an antisperm contraceptive vaccine, should be involved in the fertilization process rather than embryonic development. FA-1 has been obtained through the use of a sperm-specific but species-cross reactive monoclonal antibody (MA-24) raised against human spermatozoa. Female rabbits were chosen to study the effects of active immunization because the monoclonal antibody to FA-1 (MA-24) reacted with rabbit sperm and caused reduction in fertilization in female rabbits in passive immunization experiments. A significant reduction in fertility occurred after immunization with FA-1. The data indicate that the active immunization with FA-1 results in a tissue-specific immune response that causes a reduction of fertility in rabbits by a mechanism(s) involving an inhibition of the fertilization process. FA-1 appears at this time to be promising for the development of an antisperm contraceptive vaccine and for the diagnosis and treatment of infertility in humans mediated through antisperm antibodies.
yes........Fertilization antigen (FA-1), the antigen for the development of an antisperm contraceptive vaccine