Question

lead compound definition

Answer 1

A lead compound (i.e. a "leading" compound, not to be confused with various compounds of the metallic element lead) in drug discovery is a chemical compound that has pharmacological or biological activity likely to be therapeutically useful, but may nevertheless have suboptimal structure that requires modification to fit better to the target; lead drugs offer the prospect of being followed by back-up compounds. Its chemical structure serves as a starting point for chemicalmodifications in order to improve potency, selectivity, or pharmacokinetic parameters. Furthermore, newly invented pharmacologically active moieties may have poor druglikeness and may require chemical modification to become drug-like enough to be tested biologically or clinically.[1]

Answer 2

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➡️ lead compound in drug discovery is a chemical compound that has pharmacological or biological activity likely to be therapeutically useful, but may nevertheless have suboptimal structure that requires.


➡️ In medicine, a chemical compound that shows promise as a treatment for a disease and may lead to the development of a new drug. Once a lead compound has been found, the chemical structure is used as a starting point to make a drug that has the most benefits and the least harms.


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