Question

main difference between type I and type IV hypersensitivity​

Answer 1

Explanation:

Type IV hypersensitivity (also called delayed-type hypersensitivity [DTH]) involves T cell–antigen interactions that cause activation, cytokine secretion, and potential granuloma formation. This type of hypersensitivity requires sensitized lymphocytes that respond 24 to 48 hours after exposure to soluble antigen.Type IV hypersensitivity diseases are usually long-standing and require on-going treatment if there is flaring up of the diseases. However it does not cause life-threatening conditions such as anaphylaxis or angioedema (in type I hypersensitivity diseases)

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Answer 2

Answer:

Type 1 Hypersensitivity

1. Type 1 hypersensitivity reaction is an allergic reaction provoked by re-exposure to a specific type of antigen referred to as an allergen.
2. he reaction may be either local or systemic. Symptoms vary from mild irritation to sudden death from anaphylactic shock.
3. Some examples of type 1 hypersensitivity:

• Allergic asthma
• Allergic conjunctivitis
• Allergic rhinitis (“hay fever”)
• Anaphylaxis
• Angioedema
• Atopic dermatitis (eczema)

Type 4 hypersensitivity

1. Type 4 hypersensitivity reactions are often called delayed type as the reaction takes two to three days to develop. Unlike the other types, it is not antibody mediated but rather is a type of cell-mediated response.
2. CD8+ cytotoxic T cells and CD4+ helper T cells recognise antigen in a complex with either type 1 or type 2 major histocompatibility complex. The antigen-presenting cells in this case are macrophages which secrete IL-1, which stimulates the proliferation of further CD4+ T cells
3. Some examples:

• Contact dermatitis (poison ivy rash, for example)
• Temporal arteritis
• Symptoms of leprosy
• Symptoms of tuberculosis
• Transplant rejection
• Coeliac disease

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