Which of the following reagents will reduce a carboxylic acid to a 1^(@) -alcohol under mild conditions? (A) BH_(3)- ether (B) NaBH_(4)CH_(3)CH_(2)OH (C) H_(2) and Pt catalyst (D)LiAlH_(4) in ether
Answers
Answer:
Explanation:
3.11.1.1.1 Preparations of oximes from carbonyl compounds
Oximes are customarily prepared from the corresponding carbonyl compound, and the preparation of oximes by the addition of hydroxylamine to aldehydes or ketones has been reviewed <B-72MI 311-01>. Derivatives of hydroxylamine, e.g., NH2OSO3H and HON(SO3Na)2, have also been used.
For hindered ketones, such as hexamethylacetone, high pressures <59JA2151> or prolonged reaction times may be necessary. It has also been shown <59JA473, 64MI 311-01> that the rates of formation of oximes are at a maximum when the acidity of the mixture is about pH4.
Ketones can also be converted into their oximes by a trans-oximation reaction. Other oximes such as ethyl α-(isopropylidene)aminooxylpropionate <65JOC1307, 73OSC(5)1031>, and aldehydes or ketones can be converted into oximes using acetone oxime in acetic acid <89JPR870>.
Answer:
LiAlH_(4) in ether
Explanation;
in the above it has ability to reduce carboxylic acids