Question

Maximum cell concentration supported by oxygen transfer in the fermenter?

Answer 1

Aeration and agitation are important variables to provide effective oxygen transfer rate during aerobic bioprocesses. Hence, the knowledge of the volumetric mass transfer coefficient (kLa) is required. ... It can be described and analyzed by means of the volumetric mass transfer coefficient, kLa.

Answer 2

Explanation:

Dissolved oxygen is usually controlled at 20%–50% of the saturation concentration (Csat). To avoid oxygen limitation (i.e., dissolved oxygen is the limiting factor for cell growth), the dissolved oxygen concentration must be above a critical concentration, typically 10% of Csat.