Question

Mechanism of action of local anesthetic easily describe

Answer 1

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Here's the answer ⤵

♦ Local anesthetics produce anesthesia by inhibiting excitation of nerve endings or by blocking conduction in peripheral nerves.

♦ This is achieved by anesthetics reversibly binding to and inactivating sodium channels.

♦ Thus, the open state of the sodium channel is the primary target of local anesthetic molecules.

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Answer 2

Cocaine is a naturally occurring compound indigenous to the Andes Mountains, West Indies, and Java. It was the first anesthetic to be discovered and is the only naturally occurring local anesthetic; all others are synthetically derived. Cocaine was introduced into Europe in the 1800s following its isolation from coca beans. Sigmund Freud, the noted Austrian psychoanalyst, used cocaine on his patients and became addicted through self-experimentation.

In the latter half of the 1800s, interest in the drug became widespread, and many of cocaine's pharmacologic actions and adverse effects were elucidated during this time. In the 1880s, Koller introduced cocaine to the field of ophthalmology, and Hall introduced it to dentistry. Halsted was the first to report the use of cocaine for nerve blocks, in the United States in 1885, and also became addicted to the drug through self-experimentation.

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