Question

Mention the cause of ADA deficiency in humans. How has genetic engineering helped patients suffering from it?

Answer 1

Answer:

Deletion/mutation of the gene which forms the enzyme - adenosine deaminase. Lymphocytes from the blood of the patient, can be grown in a culture outside the body, ADA cDNA gene Ian be inserted into the lymphocyte using retroviral vector, then lymphocytes can be returned to the patient. (They can start producing ADA).Read more on Sarthaks.com - https://www.sarthaks.com/186158/mention-cause-deficiency-humans-how-genetic-engineering-helped-patients-suffering-from

Answer 2

Answer:

deletion or mutation of the gene producing adenosine deaminase causes the disease ADA deficiency it can be cured by gene therapy and it is only a temporary cure due to the GM cells inserted in the body are mortal and need to be replaced every 120 -140 days .It also have a permanent cure by embryonic gene therapy