Metabolic efficiency and amino acid composition in the proteomes of escherichia col
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Biosynthesis of an Escherichia coli cell, with organic compounds as sources of energy and carbon, requires approximately 20 to 60 billion high-energy phosphate bonds [Stouthamer, AH (1973) Antonie van Leeuwenhoek 39, 545–565]. A substantial fraction of this energy budget is devoted to biosynthesis of amino acids, the building blocks of proteins. The fueling reactions of central metabolism provide precursor metabolites for synthesis of the 20 amino acids incorporated into proteins. Thus, synthesis of an amino acid entails a dual cost: energy …
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coli can synthesize all of the amino acids from inorganic compounds and glucose but it is also capable of transporting intact amino acids into the cell from the extracellular environment. For E. coli, the amino acids can serve as a sole carbon or nitrogen source.
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