Question

Mitochondrial dysfunction causes decreased oxidative phosphorylation and ATP production, formation of
permeability transition (MPT) channels, and release of
Dorph
Cytochromec
Nackde​

Answer 1

The mitochondrial intermembrane space is the space between the outer membrane and the inner membrane. It is also known as perimitochondrial space. Because the outer membrane is freely permeable to small molecules, the concentrations of small molecules, such as ions and sugars, in the intermembrane space is the same as in the cytosol.[17] However, large proteins must have a specific signaling sequence to be transported across the outer membrane, so the protein composition of this space is different from the protein composition of the cytosol. One protein that is localized to the intermembrane space in this way is cytochrome c.[28Mitochondria may have a number of different shapes.[23] A mitochondrion contains outer and inner membranes composed of phospholipid bilayers and proteins.[17] The two membranes have different properties. Because of this double-membraned organization, there are five distinct parts to a mitochondrion:

the outer mitochondrial membrane,

the intermembrane space (the space between the outer and inner membranes),

the inner mitochondrial membrane,

the cristae space (formed by infoldings of the inner membrane), and

the matrix (space within the inner membrane).

Mitochondria stripped of their outer membrane are called mitoplasts.

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