Question

Mitochondrial quality control: the role of mitophagy in aging

Answer 1

Answer:

Autophagy serves as an integral quality control mechanism by recycling cellular constituents for energy consumption and cellular rejuvenation under basal and stress conditions.

Furthermore, defects in autophagy have been linked to mitochondria injury and cell death associated with aging.

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Answer 2

Answer -

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• HF is also characterized by increased formation and consumption of ketone bodies (KBs), which may activate mitophagy and provide an endogenous mechanism to limit the adverse effects of mitochondrial damage. However, the role of KBs in activation of mitophagy in aging and HF has not been evaluated.

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