Nhej starts with recognition of the dna ends by the ku70/80 heterodimer, which recruits dna-pkcs. If the ends are incompatible, nucleases such as artemis can trim the ends. The xrcc4-dna ligase iv-xlf ligation complex seals the break
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DNA repair protein XRCC4 also known as X- ray repair cross-complementing ... protein kinase (DNA-PKcs). Artemis cleaves the ends of damaged DNA to prepare it for ligation.
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