One of the late symptoms of MN is excessive edema, or build up of fluid within the interstitial space of tissue. Explain how loss of circulating blood protein (Hypoalbuminemia) would cause edema with respect to hydrostatic and colloid osmotic pressure within capillary beds throughout the body.
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Answer:
Edema occurs when an excessive volume of fluid accumulates in the tissues, either within cells (cellular edema) or within the collagen-mucopolysaccharide matrix distributed in the interstitial spaces (interstitial edema) [14,42,62,64,87,88,141,215,247,279]. Our focus is on swelling of the extracellular matrix or interstitial edema, which may occur as a result of aberrant changes in the pressures (hydrostatic and oncotic) acting across the microvascular walls, alterations in the molecular structures that comprise the barrier to fluid and solute flux in the endothelial wall that are manifest as changes in hydraulic conductivity and the osmotic reflection coefficient for plasma proteins, or alterations in the lymphatic outflow system, as predicted by examination of the Starling equation.
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