OPTICI. Name the following: Enzyme involved in joining of Okazaki fragments. What is velamen?
Answers
Okazaki fragments are short sequences of DNA nucleotides (approximately 150 to 200 base pairs long in eukaryotes) which are synthesized discontinuously and later linked together by the enzyme DNA ligase to create the lagging strand during DNA replication.[1] They were discovered in the 1960s by the Japanese molecular biologists Reiji and Tsuneko Okazaki, along with the help of some of their colleagues.
C Ligase
DNA ligase is a specific type of enzyme, a ligase, that facilitates the joining of DNA strands together by catalyzing the formation of a phosphodiester bond.
Okazaki fragments are short, newly
synthesized DNA fragments that are formed
on the lagging template strand during DNA replication. Enzyme ligase connects (ligates) the two
Okazaki fragments into one continuous newly synthesized complementary strand. Thus, option C is correct.